Endocrine Abstracts

Iron represents a micronutrient for cellular metabolism and aerobic respiration, and is essential for proper brain development in the fetal and early neonatal period. However, excess iron produces toxic build-up via free radical formation. In thalassaemic and juvenile hemochromatosis patients with pubertal failure, iron overload interferes with the correct function of the hypothalamic–pituitary axis, leading to hypogonadotrophic hypogonadism and growth failure, but the me...

Somatostatin (SRIF) is an inhibitory hormone that plays a regulatory role in several cell functions including cell proliferation. SRIF acts through five specific membrane receptors (sst1-5), expressed on SRIF-target cells. SRIF and ssts may play a significant role in the progression and neuroendocrine differentiation of human prostate cancer (PCa). However, conflicting results have been reported in the literature on ssts heterogeneity and specific cell localization in PCa. Aim...